In recent years, NMN (nicotinamide mononucleotide) has been attracting worldwide attention in the anti-aging field.
NMN is sometimes called the “rejuvenating vitamin,” and numerous products are available as supplements and medical treatments. However, there are many misconceptions about its effectiveness and safety.

This article provides a clear, scientifically based explanation of NMN, from basic knowledge to the latest clinical research and the differences between supplements and medical treatments.

1. What is NMN? | A key substance for generating energy in the body

NMN (β-nicotinamide mononucleotide) is a coenzyme synthesized in the body from vitamin B3 (niacin).
It functions as a precursor to NAD⁺ (nicotinamide adenine dinucleotide), which is essential for cellular energy production in the body.

Features of NMN

• Activates cellular energy metabolism
• Responds to the decline in NAD⁺ associated with aging
• Supports mitochondrial function and promotes cellular rejuvenation

It is known that the amount of NAD⁺ in the body decreases with age, leading to a decline in energy production and DNA repair capabilities.
For this reason, research has shown that supplementing with NMN may improve metabolic decline and the decline in cellular function associated with aging.

2. Clinical Research Results on NMN

NMN has attracted global attention since research at Harvard University, and numerous animal and human clinical trials have been conducted to date.

Major Research Reports

Mouse Study (2013)
NMN administration has been shown to improve metabolic decline associated with aging, and to extend athletic ability and lifespan.

Human Trials (2020 and Beyond)

• Significant increases in blood NAD⁺ levels were observed in middle-aged and elderly men and women who took NMN.
• Improvements in insulin sensitivity and vascular function were observed.
• Few side effects have been reported, and the drug is considered highly safe.

However, direct effects such as “extending human lifespan” have not been confirmed.
At this stage, it remains at the stage of “possibly alleviating functional decline due to aging.”

3. Differences between Supplements and Medical Treatments

Methods of taking NMN can be broadly divided into supplements (oral intake) and intravenous or injection therapy at a medical institution.

① NMN Supplements

• Easy to continue taking by simply taking them
• Relatively affordable
• Commercial products vary in quality (purity, content, and absorption rate vary depending on the product)
• It may take some time to feel the effects

② NMN Infusion/Injection Therapy (Medical Institution)

• High concentrations of NMN can be administered directly into the bloodstream, providing immediate results
• High cost per session (approximately ¥20,000-¥50,000)
• Safe treatment under medical supervision
• There have been reports of fatigue recovery and improved concentration when taken regularly.
• Many doctors believe that the best way to do this is to combine supplements and IV infusions depending on your constitution, age, and goals.

4. Things to Consider When Selecting NMN

There are many different NMN products on the market, but there are significant differences in quality and effectiveness.
The following points are important to consider when choosing a reliable NMN.

• Does it use high-quality NMN with a purity of 99% or more?
• Are the manufacturing process and raw material safety information publicly available?
• Is there a certificate of ingredient analysis from a third-party organization?
• Is it proven to be used in medical institutions?

Be careful, as some inexpensive products contain low amounts of NMN or are poorly absorbed by the body.

5. NMN: A Next-Generation Anti-Aging Ingredient

NMN is a “next-generation anti-aging ingredient” that supports cellular functions that decline with age and has the potential to extend healthy lifespan.
In addition to supplements, administering it via intravenous or injection therapy at a medical institution can ensure more effective absorption and immediate results.

With further research, NMN may not only slow down aging, but also become a pillar of preventive medicine for reducing the risk of age-related diseases.